Matches in Nanopublications for { ?s ?p ?o <http://purl.org/np/RA8FelCvPBxTggV1kWoWeWpAxMHigoTMJwbaz9-O2_B-g#assertion>. }
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- DOID_1574 type Disease assertion.
- context type Cohort assertion.
- association type ChemicalToDiseaseOrPhenotypicFeatureAssociation assertion.
- DB00904 type Drug assertion.
- DOID_1574 label "alcohol use disorder" assertion.
- context label "adults" assertion.
- association label "While alcohol induces an increase of dopamine, ondansetron reduces the release of the neurotransmitter by blocking the 5-HT3 receptors. Several studies investigated the effectiveness of ondansetron by dividing alcoholic individuals into two subgroups based on their genotype for the promoter region of the SLC6A4 gene coding for the serotonin transporter (5-HTTLPR L/S polymorphism). The study showed that the patients with the LL genotype treated with ondansetron responded better in terms of alcohol amount and days of abstinence, compared to the other subgroups. Based on these results, researchers have further investigated genotype LL carriers, by analyzing the role of a functional polymorphism of the SLC6A4 gene (rs1042173 [T/G] SNP). The result was that individuals who carry both 5-HTTLPR LL polymorphism and rs1042173 TT polymorphism, treated with ondansetron at the dosage of 0.5 mg/die, present a more effective response to the drug. Unfortunately, the sample of this exploratory study was too small to be validated." assertion.
- DB00904 label "Ondansetron" assertion.
- association subject DB00904 assertion.
- association predicate treats assertion.
- association object DOID_1574 assertion.
- association has_population_context context assertion.
- association relation NCIT_C94303 assertion.
- DOID_1574 category Disease assertion.
- context category Cohort assertion.
- association category ChemicalToDiseaseOrPhenotypicFeatureAssociation assertion.
- DB00904 category Drug assertion.
- association publications 29912214 assertion.
- association aggregator_knowledge_source knowledge-collaboratory assertion.