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- STAYAHEAD_AF type Dataset assertion.
- STAYAHEAD_AF type FAIRDigitalObject assertion.
- STAYAHEAD_AF label "STAYAHEAD AlphaFold-2 Mutational Variant Dataset" assertion.
- STAYAHEAD_AF comment "The resource centers on the RBD of the ancestral Wuhan-Hu-1 spike protein and includes a systematically generated set of all possible single-point missense variants (3,705 in total). All variants are annotated with structural descriptors derived from AlphaFold-2 predicted structures and augmented with sequence-based biophysical predictors such as disorder, flexibility, and amyloid aggregation propensity from the Bio2Byte suite. To complement structural predictions, empirical measurements of ACE2 binding affinity and surface expression levels were integrated for each 1-step variant, based on deep mutational scanning (DMS) data published by Starr et al. This pairing of theoretical and experimental annotations provides a foundation for analyzing structure–function relationships across the spike mutational landscape and supports downstream applications in protein modeling, variant characterization, and structure-guided surveillance." assertion.
- STAYAHEAD_AF contactPoint "info@health-holland.com" assertion.
- STAYAHEAD_AF creator 0009-0004-2188-0817 assertion.
- STAYAHEAD_AF subject c_4318 assertion.
- STAYAHEAD_AF contributor 0000-0001-8888-635X assertion.
- STAYAHEAD_AF language en assertion.
- 9tj6b license CC-BY-4.0 assertion.
- STAYAHEAD_AF publisher 056cwr036 assertion.
- 9tj6b issued "2024" assertion.
- 9tj6b accessURL 9tj6b assertion.
- STAYAHEAD_AF hasVersion "v1.0" assertion.
- STAYAHEAD_AF hasMetadata RAVLW4m4-aEKD5vnkvzf-hpqsQJQOi7Dw3DXGFqesX9hc assertion.
- 9tj6b hasEncodingFormat csv assertion.
- 9tj6b materializes STAYAHEAD_AF assertion.
- STAYAHEAD_AF funder 056cwr036 assertion.