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- association type Statement assertion.
- association label ""* When co-administering ritonavir with other protease inhibitors, see the full prescribing information for that protease inhibitor including contraindication information. Table 2. Drugs that are Contraindicated with Ritonavir Drug Class Drugs Within Class That Are Contraindicated With Ritonavir ** Clinical Comments Alpha 1 Alfuzosin HCL Potential for hypotension. Antianginal Ranolazine Potential for serious and/or life-threatening reactions. Antiarrhythmic Amiodarone,dronedarone, flecainide, propafenone, Potential for cardiac arrhythmias. Antifungal Voriconazole Voriconazole is contraindicated with ritonavir doses of 400 mg every 12 hours or greaterdue to the potential for loss of antifungal response. Anti-gout Colchicine a Potential for serious and/or life-threatening reactions in patients with renal and/or hepatic impairment. Antipsychotics Lurasidone Potential for serious and/or life-threatening reactions. Ergot Derivatives Dihydroergotamine, Potential for acute ergot toxicity characterized by vasospasm and ischemia of the extremities and other tissues including the central nervous system. GI Motility Agent Cisapride Potential for cardiac arrhythmias. Herbal Products St. John's Wort (hypericum perforatum) May lead to loss of virologic response and possible resistance to ritonavir or to the class of protease inhibitors. HMG-CoA Reductase Inhibitors: Lovastatin, simvastatin Potential for myopathy including rhabdomyolysis. PDE5 inhibitor Sildenafil b (r) Potential for sildenafil-associated adverse events, including visual abnormalities, hypotension, prolonged erection, and syncope. Sedative/hypnotics Oral midazolam c Prolonged or increased sedation or respiratory depression. a 7 Table 5 b 7 Table 5 c ( 7 Table 5 * Ritonavir is contraindicated in patients with known hypersensitivity to ritonavir (e.g., toxic epidermal necrolysis, Stevens-Johnson syndrome) or any of its ingredients (4)"" assertion.
- association subject drugbank:DB00503 assertion.
- association predicate treats assertion.
- association object DOID_13189 assertion.
- association relation MedicalContraindication assertion.
- association provided_by NeuroDKG assertion.