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- s41467-022-29206-7 type ResearchPaper assertion.
- author-list _1 0000-0002-1481-2996 assertion.
- author-list__1 _2 0000-0002-7355-0674 assertion.
- author-list__2 _3 0000-0002-8627-3813 assertion.
- author-list__3 _4 0000-0002-6937-6394 assertion.
- author-list__4 _5 0000-0003-2705-4781 assertion.
- s41467-022-29206-7 issue "13" assertion.
- s41467-022-29206-7 volume "2022" assertion.
- 0259fwx54 name "ZB MED – Information Centre for Life Sciences: Cologne, DE" assertion.
- 0000-0002-1481-2996 name "Konrad U. Förstner" assertion.
- 0000-0002-6937-6394 name "Julia García-Fernández" assertion.
- 0000-0002-7355-0674 name "Ana Eulalio" assertion.
- 0000-0002-8627-3813 name "Daniel Lopez" assertion.
- 0000-0003-2705-4781 name "Ivan C. Acosta" assertion.
- s41467-022-29206-7 title "The induction of natural competence adapts staphylococcal metabolism to infection" assertion.
- 2041-1723 title "Nature Communications (Nat Commun)" assertion.
- s41467-022-29206-7 date "2022-03-21" assertion.
- s41467-022-29206-7 isPartOf 2041-1723 assertion.
- s41467-022-29206-7 abstract "A central question concerning natural competence is why orthologs of competence genes are conserved in non-competent bacterial species, suggesting they have a role other than in transformation. Here we show that competence induction in the human pathogen Staphylococcus aureus occurs in response to ROS and host defenses that compromise bacterial respiration during infection. Bacteria cope with reduced respiration by obtaining energy through fermentation instead. Since fermentation is energetically less efficient than respiration, the energy supply must be assured by increasing the glycolytic flux. The induction of natural competence increases the rate of glycolysis in bacteria that are unable to respire via upregulation of DNA- and glucose-uptake systems. A competent-defective mutant showed no such increase in glycolysis, which negatively affects its survival in both mouse and Galleria infection models. Natural competence foster genetic variability and provides S. aureus with additional nutritional and metabolic possibilities, allowing it to proliferate during infection." assertion.
- 0000-0002-1481-2996 affiliation 0259fwx54 assertion.